在迎来崭新的2026年之际，Synthesis 回顾了过去一年与全球作者们共同取得的成绩。2025年，Synthesis收获了无数优秀研究成果，也见证了化学领域的持续创新与发展。我们特别整理了2025年度下载量最高的三篇热门论文，与您一同重温过去一年的学术亮点！
2025 高下载量论文 Top 3
Recent Applications of Triphenylmethyl (Trityl) Cations in Synthesis
Yiwei Gong, Florian F. Mulks
Carbocations, often deemed transient and unstable intermediates in organic chemistry, gained significant recognition with the awarding of the Nobel Prize in Chemistry to George A. Olah in 1995 for his work on carbocation chemistry. The triphenylmethyl (trityl) cation, a stable and versatile carbocation, has emerged as a significant player in organic reactions. This short review provides an update on the use of trityl cations as organic Lewis acids, highlighting their role in various catalytic processes. We aim to offer a comprehensive overview of the latest developments and prospects of these ions. The continued exploration of trityl cations promises to enhance their role as a valuable tool in synthetic chemistry, offering efficient alternatives to traditional inorganic or metal-based catalysts.
Douglas A. Klumpp, Titas Deb, Ryan Littich
The Casnati–Skattebøl reaction is an effective method for achieving ortho-formylation of phenols to provide salicylaldehydes. The conversion involves the reaction of magnesium phenolates with formaldehyde followed by an oxidation of the intermediate hydroxymethyl group. This reaction has been used in the synthesis of numerous biologically active substances and natural products, which is the subject of this review.
Recent Advances in Deoxygenative Thioether Synthesis Using Oxygenated Sulfur Surrogates
Long Yin Lam, Cong Ma
Thioethers (sulfides) play a crucial role in therapeutics, diagnostics, and functional materials. Traditionally, their synthesis involved the use of thiols or their derivatives, which are associated with unpleasant odors and potential health risks. Recently, significant research has focused on employing oxygenated sulfur compounds, such as sulfinates, sulfonyl derivatives, sulfur oxyacids, and sulfoxides, as thiol surrogates for thioether synthesis. This review highlights recent advancements in deoxygenative thioether synthesis, categorizing them by reaction types, including cross-coupling reactions, C–H functionalization, and hydro/halo/oxy-thiolation of unsaturated hydrocarbons. We also discuss representative mechanisms to provide a comprehensive understanding of these innovative approaches.
