Sodium Nitrite (NaNO₂): An Impressive and Efficient Nitrating/Nitrosating Reagent in Organic Synthesis

I. C. . Lamark et al.

This graphical review provides a concise overview of the key organic reactions reported in the literature that use sodium nitrite (NaNO₂) as a nitrating or nitrosating agent. It summarizes the diverse reactivity of this reagent with various substrates, leading to the functionalization and synthesis of a wide variety of useful organic molecules.

A convenient synthesis of CHF₂O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

Fluorine-containing organic molecules, including CHF₂O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF₂O-motif incorporated with azetidine, pyrrolidine (proline), piperidine, 2-azabicyclo[2.2.1]heptane, and 8-azabicyclo[3.2.1]octane cores were synthesized. A multigram scale (10 to 30 g) procedure for synthesizing title compounds from commercially available amino alcohols was studied.

Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents