Issue 03
June 2024
Editor's Choice
Janelle Vu Pugashetti, Joyce S. Lee
Overview of Rheumatoid Arthritis-Associated Interstitial Lung Disease and Its Treatment
间质性肺病（ILD）是类风湿性关节炎（RA）常见的肺部并发症，可导致严重的发病率和死亡率。RA-ILD的最佳治疗方法尚未明确。可靠的预后指标主要是先前 ILD 进展的副产品，包括低或下降的用力肺活量和影像学上广泛或恶化的纤维化。由于缺乏预测治疗反应的有效工具，是否开始或加强治疗的决定只能基于临床判断。一般来说，有症状、病情进展或面临不良后果高风险的患者应开始治疗。回顾性数据表明，霉酚酸酯、硫唑嘌呤和利妥昔单抗可能是治疗RA-ILD的有效疗法。阿巴西普也正在成为 RA-ILD 患者的潜在一线治疗选择。此外，最近的数据表明，即使对于影像学上具有常见间质性肺炎 (UIP) 模式的患者，免疫抑制也可能有益，这表明无论影像学模式如何，都应考虑免疫抑制。最近的随机对照试验表明，抗纤维化药物（如尼达尼布和可能的吡非尼酮）可减缓 RA-ILD 的用力肺活量下降。对于免疫抑制后仍有进展的患者，尤其是具有UIP模式的患者，可以考虑开始使用抗纤维化药物。未来的研究方向包括开发工具来预测哪些患者病情将保持稳定，哪些患者病情将有所进展；区分对治疗有反应的患者和无反应的患者；开发算法来启动免疫抑制剂、抗纤维化药物或两者作为一线疗法。
Guest Editors: Cormac McCarthy, MD, PhD, FRCPI, and David N. O'Dwyer, MB BCH BAO, PhD
Review Article
Zamora, Ana C.; Wesselius, Lewis J.; Gotway, Michael B.; Tazelaar, Henry D.; Diaz-Arumir, Alejandro; Nagaraja, Vivek:
Diagnostic Approach to Interstitial Lung Diseases Associated with Connective Tissue Diseases
Guo, Hui; Iqbal, Beenish; Rahman, Najib M.:
Gaffney, Brian; Murphy, David J.:
Pugashetti, Janelle Vu; Lee, Joyce S.:
Overview of Rheumatoid Arthritis-Associated Interstitial Lung Disease and Its Treatment
Mismetti, Valentine; Si-Mohamed, Salim; Cottin, Vincent:
Interstitial Lung Disease Associated with Systemic Sclerosis
Ghanbar, Mohammad I.; Danoff, Sonye K.:
Review of Pulmonary Manifestations in Antisynthetase Syndrome
Bendstrup, Elisabeth; Lynn, Evelyn; Troldborg, Anne:
Byrne, Louise; McCarthy, Cormac; Fabre, Aurelie; Gupta, Nishant:
Cullivan, Sarah; Cronin, Eleanor; Gaine, Sean:
Budhram, Brandon; Weatherald, Jason; Humbert, Marc:
Pulmonary Hypertension in Connective Tissue Diseases Other than Systemic Sclerosis
Mulcaire-Jones, Erica; Pugashetti, Janelle Vu; Oldham, Justin M.; Khanna, Dinesh:
Novel Therapeutic Approaches in Connective Tissue Disease-Associated Interstitial Lung Disease
Bongers, Kale S.; Massett, Angeline; O'Dwyer, David N.:
The Oral–Lung Microbiome Axis in Connective Tissue Disease-Related Interstitial Lung Disease
Seminars in Respiratory and Critical Care Medicine 为主题综述双月刊，提供呼吸和肺部疾病的全面报道。
本刊专注于新的诊断和治疗方法、实验室研究、遗传学研究突破、病理学、涉及哮喘和其它肺部疾病的临床特征和管理、重症监护管理、囊性纤维化、肺移植和心脏移植、呼吸道病原体和胸膜疾病以及诸多其它相关疾病。
