Issue 04
April 2024
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S. Solaipriya, M Anbalagan, V. Sivaramakrishnan
Progesterone receptor membrane component 1 (PGRMC1) is a pleiotropic protein over-expressed in lung adenocarcinoma (LUAD). The precise molecular mechanisms underlying the signature motif of Casein kinase (CK2) presence in PGRMC1 and their role in LUAD remain unclear. X-ray crystallographic structure for CK2 and PGRMC1 from the PubChem database was obtained and subjected to protein-protein interaction (PPI) analysis to identify their interactions. In addition, the CK2 inhibitor – Silmitasertib was also utilised to understand the interaction between PGRMC1-CK2. The PPI complex (PGRMC1-CK2) and the PPI-ligand interaction analysis and their Molecular Dynamics (MD) studies revealed the stability of their interactions and critical amino acid contacts within the 5Ǻ vicinity of the CK2 signature motif "T/S-x-x-E/D". Moreover, in-vitro colony formation assay, migration assay, and gene expression analysis using quantitative Real-time PCR revealed that Silmitasertib (IC50–2.5 μM) was highly influential in suppressing the PGRMC1-CK2 expression axis. In conclusion, our study infers that PGRMC1-CK-2 axis inhibition could be a potential therapeutic option to limit the promotion and progression of lung cancer.
Review
Andriolo, Ian Richard Lucena; Venzon, Larissa; da Silva, Luisa Mota:
Perspectives About Ascorbic Acid to Treat Inflammatory Bowel Diseases
Original Article
Ghosian-Moghaddam, Mohamad-Hasan; Mohseni-Moghaddam, Parvaneh; Roghani, Mehrdad:
Mehta, Geetika; Tyagi, Daksh Raj; Sachdeva, Monika; Tripathi, Rashmi; Tyagi, Himanshu:
An Observational Study on Cosmetics Use-related Adverse Effects: Cosmetovigilance Need of the Day
Boeing, Thaise; Lima, Alana Bittencourt F.; Busana, Maria Eduarda; Mariano, Luísa Nathália Bolda; da Silva, Luisa Mota; Silva, Rita de Cássia Vilhena da; de Souza, Priscila:
Rahić, Ognjenka; Behrem, Sabina; Tucak-Smajić, Amina; Hadžiabdić, Jasmina; Imamović, Belma; Hindija, Lamija; Šahinović, Merima; Vranić, Edina:
Short Communication
Solaipriya, S.; Anbalagan, M; Sivaramakrishnan, V.:
Free Access
Drug Research是国际同行评审期刊,以快速的处理时间提供新药和成熟药物分子相关的最新研究成果和新药开发评估。
本刊重点关注的是在临床环境所使用药物的开发中,转化医学和生物学发现的应用。药物研究领域的文章和实验数据不仅包括新药研发主题,还包括用于工业化研究和临床试验结果评估的数理统计学方法。
Drug Research每年出版12期,发表形式包括原创性研究、评述、评注和短报。涵盖如下领域:
应用于临床试验的分析
化学和生物化学
临床和实验药理学
药物相互作用
疗效测试
药效学
药物代谢动力学
畸形学
毒理学