Thieme Chemistry期刊Synthesis中国作者精选论文，本期论文来自以江西理工大学王瑞祥教授为第一作者的研究，欢迎阅读。

摘要 //

The copper-catalyzed synthesis of 3-vinylisocoumarin-1-imine is reported. The transformation proceeds smoothly with good yields in THF and the regioselectivity was determined by a O-nucleo­philic 6-endo cyclization. Studies on the mechanism indicate that copper trifluoroacetate serves as a Lewis acid, and the use of vinyl-connected 2-alkynylbenzamide is important for this O-nucleophilic 6-endo cyclization.

本文报道了铜催化3-乙烯基异香豆素-1-亚胺的合成。该转化在四氢呋喃中以良好的收率顺利进行，并且区域选择性通过O-亲核6-内环化。研究表明，三氟乙酸铜是一种路易斯酸，乙烯基连接的2-炔基苯甲酰胺的使用对这种O-亲核的6-内环化非常重要。

关键词 //

copper catalysis - O-nucleophilic 6-endo cyclization - Lewis acid - vinyl-connected 2-alkynylbenzamide - isocoumarin