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Synlett | 天津大学马军安教授团队最新研究 2021-01-08

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SYNLETT

Accounts and Rapid Communications in Chemical Synthesis

影响因子 2019:2.006






Thieme Chemistry期刊Synlett中国作者精选论文,本期论文来自天津大学,天津市分子光电科学重点实验室,天津化学化工协同创新中心马军安教授等人的研究,欢迎阅读。


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Silver-Catalyzed [3+3] Annulation of Glycine Imino Esters with Seyferth–Gilbert Reagent To Access Tetrahydro-1,2,4-triazinecarboxylate Esters

甘氨酸亚氨基酯与Seyferth–Gilbert 试剂进行银催化 [3 + 3] 环化反应,获得四氢 1,2,4-三嗪羧酸酯

Yin-Jun HuangJing NieChi Wai Cheung Jun-An Ma

天津大学,天津市分子光电科学重点实验室,天津化学化工协同创新中心

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摘要 //

A silver-catalyzed protocol for [3+3] annulation of glycine imino esters with Seyferth–Gilbert reagent was developed. A variety of phosphorylated tetrahydro-1,2,4-triazinecarboxylate esters were synthesized in moderate to good yields and with excellent diastereoselectivities. The dehydrogenation of a tetrahydro-1,2,4-triazine product to the corresponding triazine counterpart was also demonstrated.

开发了一种用 Seyferth-Gilbert 试剂与甘氨酸亚氨基酯进行 [3 + 3] 环化的银催化方案。合成了多种磷酸化四氢-1,2,4-三嗪羧酸酯,收率中等至良好,且具有优异的非对映选择性。还证明了四氢-1,2,4-三嗪产物脱氢为相应的三嗪对应物。

关键词 //

[3+3] annulation - glycine imino esters - Seyferth–Gilbert reagent - triazines - phosphorylation

[3+3] 环化–甘氨酸亚氨基酯–Seyferth-Gilbert 试剂–三嗪–磷酸化