Journal of Neurological Surgery Part A
影响因子2019: 0.905
Issue 6 - Volume 81 - November 2020
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Journal of Neurological Surgery Part A: Central European Neurosurgery 第6期全新上线！
本刊主编Veit Rohde教授为您精选本期论文，以吉林大学第一医院王涛博士为通讯作者的最新研究，欢迎免费阅读。
Efficacy of Platelet-rich Plasma for Low Back Pain: A Systematic Review and Meta-analysis
Zhaopeng Xuan, Wenjun Yu, Yichen Dou, Tao Wang
吉林大学第一医院
Background
Platelet-rich plasma (PRP) may be beneficial for patients with low back pain. However, the results remain controversial. We conducted a systematic review and meta-analysis to explore the efficacy of PRP for low back pain.
Methods
PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases were searched systematically. Randomized controlled trials (RCTs) assessing the effect of PRP on low back pain were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcome was pain scores within 8 weeks. Meta-analysis was performed using the random-effects model.
Results
Three RCTs involving 131 patients were included in the meta-analysis. Overall, compared with control intervention for low back pain, PRP injection was found to reduce pain scores significantly (mean difference: − 1.47; 95% confidence interval [CI], − 2.12 to − 0.81; p < 0.0001), improve the number of patients with > 50% pain relief at 3 months (risk ratio [RR]: 4.14; 95% CI, 2.22–7.74; p < 0.00001), and offer relatively good patient satisfaction (RR: 1.91; 95% CI, 1.04–3.53; p = 0.04). No increase in adverse events was reported after PRP injection (RR: 1.92; 95% CI, 0.94-3.91; p = 0.07).
Conclusions
Compared with control intervention for low back pain, PRP injection was found to improve pain relief and patient satisfaction significantly with no increase in adverse events.
Keywords
low back pain-platelet-rich plasma-pain scores-systematic review-meta-analysis
Fig. 1 Flow diagram of study searching and selection process. RCT, randomized controlled trial.
