本刊主编为您精选来自Michaela Keuper等人的一篇综述，文章关注人类循环FGF21水平及其与疾病和临床参数的相关性，主要关注肥胖及其相关疾病，如2型糖尿病。欢迎您阅读全文。

Human fibroblast growth factor 21 (FGF21) is primarily produced and secreted by the liver as a hepatokine. This hormone circulates to its target tissues (e. g., brain, adipose tissue), which requires two components, one of the preferred FGF receptor isoforms (FGFR1c and FGFR3c) and the co-factor beta-Klotho (KLB) to trigger downstream signaling pathways. In this review Keuper et al focus on circulating FGF21 levels in humans and their associations with disease and clinical parameters, focusing primarily on obesity and obesity-associated diseases such as type-2 diabetes.