Utilizing Proline Surrogates in the Synthesis of ‘Difficult’ Peptides
Contributors: Hisashi Yamamoto, Alex Boateng
Significance
The synthesis of complex peptides with sequences that readily aggregate remains a huge challenge even with conventional methods. Herein, the authors report an efficient strategy to access them.
Comment
A variety of novel 2-(oxazolidine-2-yl)phenol compounds were produced as proline surrogates and utilized in accessing ‘difficult’ peptides such as thymosin α1.
Wang X, Jin K. Shandong University, Jinan, P. R. of China
Robust Chemical Synthesis of “Difficult Peptides” via 2-Hydroxyphenol-pseudoproline (ψ2-hydroxyphenolpro) Modifications.
J. Org. Chem. 2024; 89: 3143-3149
DOI: 10.1021/acs.joc.3c02576.
SYNFACTS 对来自合成有机化学领域主要文献的当前研究结果进行筛选、选择、评估、总结，并且纳入了相关领域专家的个人评论，每月出版一期。
