C–H Functionalization for the Synthesis of Maleimide-Decorated Peptides and Macrocyclic Peptides
Contributors: Hisashi Yamamoto, Isai Ramakrishna
Significance
Late-stage functionalization plays an inherent role in the construction of peptides and macrocyclic peptides. In the present study, the authors developed a Rh(III)-catalyzed alkenylation of tryptophan-containing peptides for the synthesis of maleimide-decorated peptides and macrocyclic peptides.
Comment
Rh(III)-catalyzed alkenylation of tryptophan-containing peptides proceeded smoothly to deliver maleimide-decorated peptides in good yields with excellent selectivity. The intramolecular reaction of maleimide-decorated peptides produced macrocyclic peptides.
Rh(III)-catalyzed alkenylation of tryptophan-containing peptides proceeded smoothly to deliver maleimide-decorated peptides in good yields with excellent selectivity. The intramolecular reaction of maleimide-decorated peptides produced macrocyclic peptides.
Macrocyclization of Maleimide-Decorated Peptides via Late-Stage Rh(III)-Catalyzed Trp(C7) Alkenylation
Org. Lett. 2023; 25: 2456-2460
DOI: 10.1021/acs.orglett.3c00601.
