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SYNTHESIS | 精选论文,免费阅读 2020-11-17

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Synthesis

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Chemical Synthesis







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[3+2]-Cycloaddition of α-Diazocarbonyl Compounds with Arenediazonium Salts Catalyzed by Silver Nitrate Delivers 2,5-Disubstituted Tetrazoles

硝酸银催化的α-重氮羰基化合物和芳基重氮盐进行[3+2]环加成反应得到2,5-取代的四唑

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已经开发了芳族重氮鎓盐与重氮化合物的[3 + 2]-环加成反应(先前仅以三甲基甲硅烷基重氮甲烷和2,2,2-三氟重氮乙烷为例),已包括了多种容易获得的α-重氮羰基化合物。所得的2-芳基-5-酰基-2H-四唑在医学化学中具有很高的价值。

[3+2]-Cycloaddition of arenediazonium salts with diazo compounds (earlier exemplified only for trimethylsilyldiazomethane and 2,2,2-trifluorodiazoethane) has been developed to include a wide range of readily available α-diazocarbonyl compounds. The resulting 2-aryl-5-acyl-2H-tetrazoles are of high value in medicinal chemistry.

关键词:α-重氮羰基化合物,苯磺酸氮杂氮鎓,四唑,[3 + 2]-环加成反应,硝酸银