Issue 01
January 2024
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Kroiss, Matthias; Bechmann, Nicole:
When younger fellows ask for guidance on how to choose a research project, many aspects require consideration: how to select a supervisor and mentor, should one change the institution, how does the project boost the later professional career, what are personal and professional aims. As many can probably relate it is passion for the research topic, both by the fellow and the mentor, that will go a long way and most often result in successful project completion.
Kienitz T et al.
Adrenal Crisis – Definition, Prevention and Treatment: Results from a Delphi Survey
Based on recent data, a total number of about 29 000 patients with adrenal insufficiency can be calculated for Germany, and about 1500 fatalities due to adrenal crises have to be expected within the next decade. Management of adrenal crises is still unsatisfactory. The objectives of this study were to establish consensus for diagnostic criteria, prevention strategies, and treatment recommendations for adrenal crises. The study was conducted from January 2022 to April 2023, using Delphi technique. Four rounds of questionnaires were sent to 45 experts, selected by a coordinating group on behalf of the adrenal section of the German Society of Endocrinology.
Schwarzlmueller P et al.
The response rate of advanced adrenocortical carcinoma (ACC) to standard chemotherapy with mitotane and etoposide/doxorubicin/cisplatin (EDP-M) is unsatisfactory, and benefit is frequently short lived. Immune checkpoint inhibitors (CPI) have been examined in patient’s refractory to EDP-M, but objective response rates are only approximately 15%. High-dose rate brachytherapy (HDR-BT) is a catheter-based internal radiotherapy and expected to favorably combine with immunotherapies. Here we describe three cases of patients with advanced ACC who were treated with HDR-BT and the CPI pembrolizumab. None of the tumors were positive for established response markers to CPI. All patients were female, had progressed on EDP-M and received external beam radiation therapy for metastatic ACC.
Issue 01 · Volume 56 · January 2024
The Adrenal Gland
Editorial
Kroiss, Matthias; Bechmann, Nicole:
Original Article: Endocrine Care
Kienitz, Tina; Bechmann, Nicole; Deutschbein, Timo; Hahner, Stefanie; Honegger, Jürgen; Kroiss, Matthias; Quinkler, Marcus; Rayes, Nada; Reisch, Nicole; Willenberg, Holger Sven; Meyer, Gesine:
Adrenal Crisis – Definition, Prevention and Treatment: Results from a Delphi Survey
Wäscher, Hanna; Knauerhase, Andreas; Klar, Bettina; Postrach, Till; Weber, Marc-André; Willenberg, Holger Sven:
Chifu, Irina; Quinkler, Marcus; Altieri, Barbara; Hannemann, Anke; Völzke, Henry; Lang, Katharina; Reisch, Nicole; Pamporaki, Christina; Willenberg, Holger Sven; Beuschlein, Felix; Burger-Stritt, Stephanie; Hahner, Stefanie:
Schwarzlmueller, Paul; Corradini, Stefanie; Seidensticker, Max; Zimmermann, Petra; Schreiner, Jochen; Maier, Tanja; Triebig, Alexandra; Knösel, Thomas; Pazos, Montserrat; Pfluger, Thomas; Weigand, Isabel; Belka, Claus; Ricke, Jens; Reincke, Martin; Schmidmaier, Ralf; Kroiss, Matthias:
Kiewert, Cordula; Jedanowski, Julia; Hauffa, Berthold P.; Petersenn, Stephan; Mann, Klaus; Führer, Dagmar; Unger, Nicole:
Original Article: Endocrine Research
Weniger, Maximilian; Mattes, Maria; Grünewald, Thomas G.P.; Köhler, Katrin; Hübner, Angela; Beuschlein, Felix; Reisch, Nicole:
Review
Karna, Bhargavi; Pellegata, Natalia Simona; Mohr, Hermine:
Animal and Cell Culture Models of PPGLs – Achievements and Limitations
Cozma, Diana; Siatra, Panagiota; Bornstein, Stefan R.; Steenblock, Charlotte:
Sensitivity of the Neuroendocrine Stress Axis in Metabolic Diseases
Pötzl, Benedikt; Kürzinger, Lydia; Stopper, Helga; Fassnacht, Martin; Kurlbaum, Max; Dischinger, Ulrich:
Kimpel, Otilia; Dischinger, Ulrich; Altieri, Barbara; Fuss, Carmina Teresa; Polat, Bülent; Kickuth, Ralph; Kroiss, Matthias; Fassnacht, Martin:
Current Evidence on Local Therapies in Advanced Adrenocortical Carcinoma
Chen, Li; Adolf, Christian; Reincke, Martin; Schneider, Holger:
Salt and Aldosterone – Reciprocal and Combined Effects in Preclinical Models and Humans
