Photoinduced Cobalt-Catalyzed Enantioselective Reductive Addition of Aryl Iodides to Aldehydes
Contributors: Mark Lautens, Jeanne Masson-Makdissi
Significance
A photoredox cobalt-catalyzed enantioselective approach to a Grignard-type addition of aryl iodides to aldehydes is reported. Notably, the mild reaction conditions enable a wide range of functional groups and heterocycles to be tolerated.
Comment
4CzIPN is used as the photocatalyst, which can be excited under visible-light irradiation. The use of Hantzsch ester as the reductant is notable because it avoids the generation of stoichiometric metal waste.
Jiang X, Jiang H, Yang Q, Cheng Y, Lu L.-Q, *, Tunge JA, Xiao W.-J. * Central China Normal University, Wuhan, Lanzhou Institute of Chemical Physics (LICP), Henan Normal University, Xinxiang, and Lanzhou University, P. R. of China
Photoassisted Cobalt-Catalyzed Asymmetric Reductive Grignard-Type Addition of Aryl Iodides
J. Am. Chem. Soc. 2022; 144: 8347-8354
DOI: 10.1021/jacs.2c02481.
