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有机精选 | 用芳基(重氮)乙酸酯对吲哚进行无金属催化剂蓝光诱导环丙烷化 2021-12-07

Synthesis 2019; 51(04): 889-898
DOI: 10.1055/s-0037-1610668

Paper

Xing ZhangCong DuHe ZhangXiao-Cai LiYun-Long WangJun-Long NiuMao-Ping Song

Metal-Free Blue-Light-Mediated Cyclopropanation of Indoles by Aryl(diazo)acetates

用芳基(重氮)乙酸酯对吲哚进行无金属催化剂蓝光诱导环丙烷化

开发了用芳基(重氮)乙酸酯对吲哚进行无金属催化剂蓝光诱导环丙烷化的方法。该策略的突出特征为无需采用金属催化剂,操作简单,原子经济性高,且采用环境友好的能量来源。该反应方案中,蓝光为该化学转化的唯一能量来源。在温和条件下,以中等到极高的收率和极高的非对映立体选择性生产得到各种不同的环丙烷-吲哚化合物。

Blue-light-mediated cyclopropanation of indoles with aryl(diazo)acetates has been developed. The salient features of this strategy are that it is metal-free, operationally simple and atom-efficient, and that it uses an environmentally friendly energy source. In this protocol, blue light was employed as the sole energy source for the transformation. A variety of cyclopropane-fused indoline compounds was obtained in moderate to excellent yields and high diastereoselectivities under mild conditions.

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Synthesis

3.157  ↑18%

Impact Factor 2020

本刊为国际性论文全文期刊,致力于推动合成化学科学的发展。它涵盖了所有涉及合成有机化学领域,包括催化、有机金属、医药、生物学和光化学,也包括其他相关学科。SYNTHESIS上的内容翔实地记载了实验流程,完整地描述了所有重要新产品,提供了可靠的研究成果和科学原始数据。