本期为您推荐Thieme医学期刊Experimental and Clinical Endocrinology & Diabetes在2019年被引次数排名前五的论文。以中国医科大学附属第一医院王秋月教授为通讯作者的论文Klotho Restraining Egr1/TLR4/mTOR Axis to Reducing the Expression of Fibrosis and Inflammatory Cytokines in High Glucose Cultured Rat Mesangial Cells入榜。免费阅读或下载本期推荐论文PDF版，关注微信后回复“409”即可。
Groener JB et al.
| Table 1 Number of PubMed references found for targeted keywords.
Metastatic Phaeochromocytoma: Spinning Towards More Promising Treatment Options
Nölting S et al.
| Fig. 2 Current and potential future therapeutic options for PCC/PGL
Stangl MK et al.
| Table 1 Currently available anti-diabetic drugs and their effects on muscle integrity.
Kamilaris CDC et al.
| Fig. 1 The protein kinase A pathway: 1) Ligand binds to G-protein coupled receptor (GPCR) on the plasma membrane. This catalyzes exchange ofGTP for GDP on the α subunit of the associated heterotrimeric G protein, with dissociation of the α subunit from the βγ dimer; 2) The α subunit binds to adenylyl cyclase (AC) and activates its enzymatic activity. Activated AC produces cyclic AMP (cAMP) from ATP; 3) cAMP binds to the regulatory subunits (R) of protein kinase A (PKA) which allows for release of the catalytic subunits (c) of PKA, that then mediate serine-threonine phosphorylation of target molecules, including the transcription factor CREB (cAMP response element-binding protein).
Wu C et al.
| Fig. 6 Rapamycin, the mTOR pathways specific inhibitor, significantlyreduces the protein expression of TLR4 and Egr1 stimulated by high glucose in RMCs. RMCs were pre-incubated with 100 nmol/L rapamycin ( + RA) for 2 h before stimulating with high glucose (HG, 30 mmol/L glucose), and incubated for 2 h for detection of Egr1 and 24 h for detection of TLR4. Protein expression was determined by western blot. * p < 0.05, * * p < 0.001 vs. RMCs cultured with high glucose media. #p < 0.001 vs. RMCs cultured with high glucose media. All results represent means ± SD obtained from 3 independent experiments and normalized to GAPDH. TLR4: toll like receptor 4; Egr1, early growth response factor 1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.
Issues per year : 10
Volume : 128
Year : 2020
ISSN : 0947-7349
影响因子2018: 1.927
本刊发表内分泌学和糖尿病学各个领域的优秀论文，从分子生物学到临床研究，它都是一个很好的资源。自1983年英文版出版以来，本刊的知名度稳步提升，反映了其在这一领域的重要性。每期都会出版论著和短文，以及针对当前主题的评论。此外，每年都会出版增刊，介绍国家和国际科学会议摘要或论文集。
本刊最初以德文出版，现在仍然是德语市场上历史最悠久的内分泌学期刊！
