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Acyl Radical Chemistry via Visible-Light Photoredox Catalysis
A. Banerjee et al.
Visible-light photoredox catalysis enables easy access to acyl radicals under mild reaction conditions. Reactive acyl radicals, generated from various acyl precursors such as aldehydes, α-keto acids, carboxylic acids, anhydrides, acyl thioesters, acyl chlorides, or acyl silanes, can undergo a diverse range of synthetically useful transformations, which were previously difficult or inaccessible. This review summarizes the recent progress on visible-light-driven acyl radical generation using transition-metal photoredox catalysts, metallaphotocatalysts, hypervalent iodine catalysts or organic photocatalysts.
Enantioselective Electrochemical Lactonization Using Chiral Iodoarenes as Mediators
W.-C. Gao et al.
The enantioselective electrochemical lactonization of diketo acid derivatives using chiral iodoarenes as redox mediators is reported for the first time. Good to high stereoselectivities are observed in the lactonization and also in intermolecular α-alkoxylations of diketo ester derivatives. This enantioselective process was then adapted to an electrochemical flow microreactor where only small amounts of supporting electrolyte were necessary.
Sulfoxonium Ylide Derived Metal Carbenoids in Organic Synthesis
J. Vaitla, A. Bayer
As pioneered by Corey and Chaykovsky, sulfoxonium ylides have had widespread application in organic synthesis for more than a half century. In most of the reactions, sulfoxonium ylides were used to react with electrophiles. Under suitable reaction conditions these ylides can generate metal carbenoids and react with nucleophiles. By combining the typical reactivity of sulfoxonium ylides with transition-metal catalysis, a growing number of investigations have expanded their application in organic synthesis. This review provides an update on the preparation of sulfoxonium ylides and their applications in carbenoid transfer reactions.
Recent Developments in Polyene Cyclizations and Their Applications in Natural Product Synthesis
A. G. M. Barrett et al.
Cascade polyene cyclization reactions are highly efficient and elegant bioinspired transformations that involve simultaneous multiple bond constructions to rapidly generate complex polycyclic molecules. This review summarizes the most prominent work on a variety of cationic and radical cascade cyclizations and their applications in natural product synthesis published between 2014 and 2018.
D. Kurandina et al.
The Heck reaction is one of the most reliable and useful strategies for the construction of C–C bonds in organic synthesis. However, in contrast to the well-established aryl Heck reaction, the analogous reaction employing alkyl electrophiles is much less developed. Significant progress in this area was recently achieved by merging radical-mediated and transition-metal-catalyzed approaches. This review summarizes the advances in alkyl Heck-type reactions from its discovery early in the 1970s up until the end of 2018.
Endoscopy
Issues per year : 24
Volume : 52
Year : 2020
ISSN : 0039-7881
影响因子 2018：2.867
SYNTHESIS为国际性论文全文期刊，致力于推动合成化学科学的发展。它涵盖了所有涉及合成有机化学领域，包括催化、有机金属、医药、生物学和光化学，也包括其他相关学科。SYNTHESIS 上的内容翔实地记载了实验流程，完整地描述了所有重要新产品，提供了可靠的研究成果和科学原始数据。
