通过将β-乙硫基-β-吲哚基-α,β-不饱和酮与盐酸羟胺发生区域选择性环合反应，为异构 3-[异噁唑-3(或5)-基]吲哚的合成开发了一种简单高效互补和区域选择性合成方法。试验发现，在存在过量 NaOEt 和 EtOH 回流条件下进行环合反应，可以高收率得到 3-[异噁唑-5-基]吲哚，而采用 NaOAc 在沸腾 AcOH 中环合，可以高收率得到 3-[异噁唑-3-基]吲哚。

A simple and efficient method for the complementary and regioselective synthesis of isomeric 3-(isoxazol-5-yl)indoles and 3-(isoxazol-3-yl)indoles has been developed by the regioselective cyclocondensation reaction of β-ethylthio-β-indolyl-α,β-unsaturated ketones and hydroxylamine hydrochloride. It was found that the cyclocondensation reaction in the presence of excess NaOEt in refluxing EtOH gives 3-(isoxazol-5-yl)indoles in good yields, whereas using NaOAc in boiling AcOH gives 3-(isoxazol-3-yl)indoles in good yields.