Thieme Chemistry

Highly Evaluated Publications

in Chemical Synthesis

Issue 05 · Volume 32 · March 2021

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Preface – “The Power of Transition Metals: An Unending Well-Spring of New Reactivity” in honor of Prof. Barry Trost and 20 Years of the Thieme reference work Science of Synthesis

G. Molander

I am very pleased and honored to introduce the SYNLETTSpecial issue “The Power of Transition Metals: An UnendingWell-Spring of New Reactivity” in honor of Prof. Barry Trostand 20 Years of the Thieme reference work Science of Synthesis. As a former postdoctoral research associate in Professor Trost’s group at the University of Wisconsin, Madison, Ican state unequivocally that my years spent there wereamong the most consequential of my career, and thus thedebt I owe him is immeasurable. Barry Trost was a foundingfather of the Science of Synthesis series published by Thiemeand has been a Member of the Editorial Board for over 20years now. Science of Synthesis is a reference work that hasbeen designed to address the chemistry information needsof the organic synthetic chemist and, more specifically, tohelp all those involved in designing organic syntheticroutes, whether for research purposes or teaching and/orlearning, by providing trusted and reliable information onthe best synthetic methods available. So far, over 2,000 expert authors have written insightful full-text reviews forthis resource, which is used by chemists worldwide(sos.thieme.com).

Issue 06 · Volume 53 · March 2021

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Direct Oxidation of Primary Alcohols to Carboxylic Acids

V. Synthesis Cherepakhin, T. J. Williams

Oxidation of primary alcohols to carboxylic acids is a fundamental transformation in organic chemistry, yet despite its simplicity, extensive use, and relationship to pH, it remains a subject of active research for synthetic organic chemists. Since 2013, a great number of new methods have emerged that utilize transition-metal compounds as catalysts for acceptorless dehydrogenation of alcohols to carboxylates. The interest in this reaction is explained by its atom economy, which is in accord with the principles of sustainability and green chemistry. Therefore, the methods for the direct synthesis of carboxylic acids from alcohols is ripe for a modern survey, which we provide in this review.