Thieme Chemistry期刊Synlett中国作者精选论文，本期论文来自中国科学技术大学化学与材料科学学院傅尧教授等人的研究，欢迎阅读。

摘要 //

A cobalt-catalyzed decarboxylative methylation of aliphatic redox-active esters [N-(acyloxy)phthalimides; RAEs] with trimethylaluminum under mild conditions was developed, providing a method for transforming a carboxylate group into a methyl group without redox fluctuation. Primary and secondary RAEs were both amenable substrates, whereas a tertiary RAE delivered an elimination product. Triethylaluminum was also used to deliver a decarboxylative ethylation product.

开发了一种用三甲基铝在温和条件下进行钴催化脂族氧化还原活性酯 [N-(酰氧基)邻苯二甲酰亚胺；RAE] 的脱羧甲基化反应，提供了一种在没有氧化还原波动的情况下将羧酸酯基团转化为甲基的方法。初级和次级 RAE 都是合适的底物，而三级 RAE 则提供了消除产物。三乙基铝也用于递送脱羧乙基化产物。

关键词 //

cobalt catalysis - decarboxylative methylation - ethylation - trimethylaluminum - redox-active esters

钴催化–脱羧甲基化-乙基化–三甲基铝–氧化还原活性酯